The Most Recent Evidence

As presented at the 2023 Endocrine Society Conference, Chicago, IL

Citation: Papadopoulou-Marketou, N., Papageorgiou, A., Vavetsis, G., Panagiotis, T., & Chrousos, G. P. (2023, June). Brief, low-impact, high-intensity osteogenic loading training utilizing proprietary OsteoStrong devices with once-a-week, 10 minute treatments improves bone mineral density in women with osteoporosis of the lumbar spine. Presentation at the Endocrine Society conference, Chicago, IL.

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The Science Behind Osteogenic Loading

Addressing Bone Density, Osteoporosis and Osteopenia

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OsteoStrong – Spectrum

OsteoStrong sessions utilize a series of devices that allow axial compression of bone to emulate the effect of impact, which is called Osteogenic Loading. Because of the optimized positioning of the human body, loading forces go through the human bone that are far higher than those seen in daily activity or weight training. Heavy loading is already understood and recommended by all international bodies of medical education, but at OsteoStrong, we make it safer. In fact, we’ve known for over 100 years that Osteogenic Loading works. In the late 1800’s, Dr. Julius Wolff discovered that bones will adapt to the loads under which they are placed (Wolff’s Law). What we didn’t know until the 2012 Deere & Tobias study (below) was that there is a minimum threshold to triggering osteogenesis. 4.2 multiples of your body weight is the minimum required force to trigger bone growth in the hip joint (the most important place to avoid fracture) and peak forces with adults in conventional resistance exercise only show 1.26 to 1.54 multiples of body weight. The Surgeon General stated that increases in bone mineral density to prevent or reverse the effects of osteoporosis are stimulated by maximum loading on the musculoskeletal system. Regular, proper use of the OsteoStrong System enables the user to safely achieve such maximum loading, and therefore helps combat the effects of osteoporosis.

Walking, Running and Weighlifting & Bone Density

Learn why walking, running and even weight lifting have little to no positive effect to improving bone density. 

Rebuilding Bone Tissue Without Bisphosphonates

Learn how osteogenic loading works with and without bisphosphonates and how your body is perfectly capable of rebuilding bone tissue holistically. (Study by Osteoporosis International, 2013)

Efficacy of Osteogenic Loading (Women over 50)

Evidence of the efficacy of osteogenic loading with a group of women over the age of 50. (Hunte, Jaquish, Huck 2015 Study)

Performance of Osteogenic Loading-Type Resistance Therapy (Postmenopausal Females)

Axial Bone Osteogenic Loading-Type Resistance Therapy Showing BMD and Functional Bone Performance Musculoskeletal Adaptation Over 24 Weeks with Postmenopausal Female Subjects. (Journal of Osteoporosis & Physical Activity, 3(146), 2)

Osteogenic Loading and A1C levels

Learn how Osteogenic Loading lowered A1C levels by .6% in only 6 months without changing their diet. (Type II Diabetes 2015 Study)

Breaking Free of Fear

Gain Confidence by Building Bone Density, Strength and  Balance

The fear avoidance cycle is a self-perpetuating pattern of behavior that can develop in response to FEAR of pain, injury, or re-injury. It can lead to decreased physical activity, worsening health, and increased disability.

Today, let’s talk about FEAR specifically fear avoidance. Fear can hold us back from living an active and fulfilling life, but with the right tools and mindset, we can overcome these obstacles. Join me as we explore effective strategies and empowering insights to help you take control of your health journey

Weight-Bearing Exercises or Something Else?

Optimizing Exercises For Bone Health

Are you ready to optimize your exercise routine for bone health? In this video, we’ll discuss the differences between weight-bearing and load-bearing exercises and why load-bearing exercises are crucial for improving bone mineral density.

What Causes a Hip Fracture?

Hip Fracture Prevention Strategies

Hip fractures are a significant cause of morbidity and mortality, particularly in older adults. The incidence of hip fractures increases with age and is more common in women than men. Hip fractures result in considerable pain, disability, and decreased quality of life, and they are a leading cause of institutionalization in older adults. In this newsletter, we will discuss two types hip fractures, their causes, risk factors, and prevention strategies.

Single Leg Stance

The Cornerstone of Gait, Balance, Stability

Have you ever pondered over the reason why some people find it challenging to walk due to a lack of balance or appearing hesitant when they move, while others seem to move smoothly without any effort? The key lies in mastering the single leg stance, which is fundamental to achieving a stable gait, balance, and overall stability. This video aims to delve into the significance of retaining or regaining this crucial ability and offer insights on the measures you can adopt to accomplish it.

More Research

  1. Camacho, P. MD, Reyan, K Exercise and Osteoporosis Endocrineweb 2009. This article correlates the adaptive responses of bone and muscular tissues as they respond to loading. Load bearing exercise builds and maintains healthy bones that are less prone to osteoporosis related fracture. mobility among frail residents of nursing homes up to 96 years of age.
  2. Heinonen, A., Kannus, P., Sievanen, H., Oja, P., Pasanen, M., Rinne, M., Uusi-Rasi, K. Randomized Controlled Trial of Effect of High-Impact Exercise on Selected Risk Factors for Osteoporotic Fractures The Lancet 1996, Nov; p 1343-1347. The purpose of this randomized controlled study was to evaluate, in premeno- pausal women, the effects of high-impact loading on several determinants of osteoporotic fractures.
  3. Kemmler, W., Lauber, D., Weineck, J., Hensen, J., Kalender, W., Engelke, K. Benefits of 2 Years of Intense Exercise on Bone Density, Physical Fitness, and Blood Lipids in Early Postmenopausal Osteopenic Women Arch Intern Med. 2004;164:1084-109. This study shows that early postmenopausal women can reduce bone mass loss by maximum strength type exercise.
  4. Kemmler, W., Engelke, K., von Stengel, S. Long-Term Four-Year Exercise Has a Positive Effect on Menopausal Risk Factors: The Erlangen Fitness Osteoporosis Prevention Study Journal of Strength and Conditioning Research 2007; p. 232-239. This study demonstrated that exercise stimulus using high loads has positive affect relevant to menopausal risk factors and, therefore, may be individually considered as an alternative to hormone replacement therapy.
  5. Kontulainen, S., Heinonen, A., Kannus, P., Passanen, M., Sievanen, H., Vuori, I. Former Exercisers of an 18-month Intervention Display Residual aBMD Benefits Compared with Control Women 3.5 years Post-Intervention: A Follow-up of a Randomized Controlled High-Impact Trial Osteoporosis International 2004, Mar; p 248-251. The findings of this study suggest that high-impact exercise has a long-term benefits in BMD for premenopausal women.
  6. Mayoux-Benhamou, M A., Leyge, J., Roux, C., Revel, M Cross-Sectional Study of Weight-Bearing Activity on Proximal Femur Bone Mineral Density Calcified Tissue International February, 1999; Volume 64, Number 2. The results of this study demonstrate the maximal loading effects over 5 years showing that those individuals that participated in this kind of activity had signifi- cantly higher BMD.
  7. Wang, Q., Alen, M., Nicholson, P., Suominem, H., Koistinen, A., Kroger, H., Cheng, S. Weight-Bearing, Muscle Loading and Bone Mineral Accrual in Pubertal Girls-A 2-Year Longitudinal Study Journal of the International Bone and Mineral Society 2007, May; 1196-1202. This study shows BMD gain as a result of impact training (maximal voluntary contraction) in pubertal female subjects.
  1. Capodagilo, P., Capodagilo, E., Faciolo, M., and Saibene, F. Long-term strength training for community-dwelling people over 75: impact on muscle function, functional ability and life style European Journal of Applied Physiology 2007, Jul; p 535-542. This study shows that the amount of habitual physical activity and live-span of both males and females over the age of 75 can be improved by engaging in high- intensity resistance loading of the body.
  2. Fisher, W., and White, M. Training-Induced Adaptations in the Central Command and Peripheral Reflex Components of the Pressor Response to Isometric Exercise of the Human Triceps Surae Journal of Physiology 1999, Oct; p 621-628. Conclusive evidence is shown in this study for a central nervous response in rela- tion to added function of one limb as a result of training to the other, in this case, non-trained limb.
  3. Miyaguchi, M., Kobayashi, A., Kadoya, Y., Ohashi, H., Yamano, Y., Takoaka, K. Biochemical Change in Joint Fluid After Isometric Quadriceps Exercise for Patients with Osteoarthritis of the Knee Osteoarthritis and Cartilage 2003, Apr; p 252-259. This study shows isometric quadriceps exercise resulting in significant changes in joint fluid biochemical parameters, and these changes, at least in part, may explain the positive effect of muscle exercise for osteoarthritis of the knee.
  4. Topp, R., Wolley, S., Hornyak, J., Khuder, S., Kaheleh, B. The Effect of Dynamic Versus Isometric Resistance Training on Pain and Functioning Among Adults with Osteoarthritis of the Knee. Archives of Physical Medicine and Rehabilitation 2002, Sep; p 1187-1195. This study shows that dynamic or isometric resistance training improve functional ability and reduce knee joint pain of patients with knee osteoarthritis. This study concludes that maximal loading of the body in exercise leads to significant gains in muscle strength, size, and functional mobility.
  1. Fiatarone, M., Marks, E., Ryan, N., Meredith, C., Lipsitz., Evans, W. High-Intensity Strength Training in Nonagenarians Effects on Skeletal Muscle The Journal of the American Medical Association 1990, Jun; p 3029-3031.
  2. Henwood, TR., Riek, S., and Taaffe DR. Strength Versus Muscle Power-Specific Resistance Training in Community– Dwelling Older Adults Journal of Gerontology 2008, Jan; p 83-91. Both strength and power improved in the subjects of this study using both dynamic and isometric modalities. Subjects used were independent adults ages 65 to 84 years old.
  1. Huck, C. & Jaquish, J. (2015). Functional bone performance measurements and adaptations using novel self-applied bone- loading exercise apparatus. Osteoporosis International. 26(1),s391s392,NS12.

  2. Jaquish, J. (2013). Multiple-of-bodyweight axial bone loading using novel exercise intervention with and without bisphosphonate use for osteogenic adaptation. Osteoporosis International. 198; 24(4), s594-s595.

  3. Mookerjee, S., & Ratamess, N. (1999). Comparison of strength differences and joint action durations between full and partial range-of-motion bench press exercise. The Journal of Strength & Conditioning Research,13(1), 76-81.

  4. Taaffe, D. R., Robinson, T. L., Snow, C. M., & Marcus, R. (1997). High-Impact Exercise Promotes Bone Gain in Well-Trained Female Athletes. Journal of bone and mineral research, 12(2), 255260.

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